OEM Custom ngwugwu eke Macrocephalae Rhizoma mmanụ

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Dị ka onye na-ahụ maka chemotherapeutic na-arụ ọrụ nke ọma, a na-etinye 5-fluorouracil (5-FU) n'ọtụtụ ebe maka ọgwụgwọ ọrịa etuto ahụ na tract gastrointestinal, isi, olu, obi, na ovary. Na 5-FU bụ ọgwụ mbụ maka ọrịa cancer colorectal na ụlọ ọgwụ. Usoro nke 5-FU bụ igbochi mgbanwe nke uracil nucleic acid n'ime thymine nucleic acid na cell tumor, wee metụta njikọ na nhazi nke DNA na RNA iji nweta mmetụta cytotoxic ya (Afzal et al., 2009; Ducreux et al. al., 2015; Longley et al., 2003). Otú ọ dị, 5-FU na-emepụtakwa afọ ọsịsa na-akpata chemotherapy (CID), otu n'ime mmeghachi omume ọjọọ na-emetụta ọtụtụ ndị ọrịa (Filho et al., 2016). Mmetụta nke afọ ọsịsa na ndị ọrịa a na-emeso ya na 5-FU ruru 50%-80%, nke metụtakwara ọganihu na ịdị irè nke chemotherapy (Iacovelli et al., 2014; Rosenoff et al., 2006). N'ihi ya, ọ dị oke mkpa ịchọta ọgwụgwọ dị irè maka 5-FU induced CID.

Ka ọ dị ugbu a, a na-ebubata ihe ndị na-abụghị ọgwụ na ọgwụ ọjọọ na ọgwụgwọ ụlọ ọgwụ nke CID. Ntinye aka na-abụghị ọgwụ na-agụnye nri ezi uche dị na ya, na ịgbakwunye nnu, shuga na nri ndị ọzọ. A na-ejikarị ọgwụ ndị dị ka loperamide na octreotide na ọgwụgwọ ọrịa afọ ọsịsa nke CID (Benson et al., 2004). Na mgbakwunye, a na-anabatakwa ethnomedicines iji gwọọ CID na ọgwụgwọ pụrụ iche nke ha na mba dị iche iche. Ọgwụ ndị China ọdịnala (TCM) bụ otu ụdị ethnomedicine nke emegoro ihe karịrị afọ 2000 na mba East Asia gụnyere China, Japan na Korea (Qi et al., 2010). TCM na-ekwusi ike na ọgwụ chemotherapeutic ga-akpalite oriri Qi, ụkọ splin, afọ adịghị mma na iru mmiri endophytic, na-ebute arụrụ arụ nke eriri afọ. Na tiori TCM, usoro ọgwụgwọ nke CID kwesịrị ịdabere na mgbakwunye Qi na ịgba ume splin (Wang et al., 1994).

Na akpọnwụ mgbọrọgwụ nkeAtractylodes macrocephalaKoidz. (AM) naPanax ginsengCA Mey. (PG) bụ ọgwụ ahịhịa a na-ahụkarị na TCM nwere otu mmetụta nke ịgbakwụnye Qi na ịgba ume splin (Li et al., 2014). A na-ejikarị AM na PG eme ihe dị ka ụzọ ahịhịa (ụdị kachasị mfe nke ndakọrịta ahịhịa ndị China) yana nsonaazụ nke ịgbakwunye Qi na ịgba ume splin iji gwọọ afọ ọsịsa. Ọmụmaatụ, AM na PG bụ ndị e dekọrọ na oge gboo mgbochi afọ ọsịsa usoro dị ka Shen Ling Bai Zhu San, Si Jun Zi Tang siTaiping Huimin Heji Ju Fang(Ụdị ndị eze egwu, China) na Bu Zhong Yi Qi Tang sitere naPi Wei Lun(Ụdị ndị eze Yuan, China) (Fig 1). Ọtụtụ ọmụmụ gara aga akọwo na usoro atọ a nwere ikike ibelata CID (Bai et al., 2017; Chen et al., 2019; Gou et al., 2016). Na mgbakwunye, ọmụmụ anyị gara aga gosiri na Shenzhu Capsule nke nwere naanị AM na PG nwere mmetụta nwere ike na ọgwụgwọ afọ ọsịsa, colitis (ọrịa xiexie), na ọrịa eriri afọ ndị ọzọ (Feng et al., 2018). Agbanyeghị, ọ nweghị ọmụmụ atụlela mmetụta na usoro AM na PG n'ịgwọ CID, ma ọ bụ na njikọta ma ọ bụ naanị ya.

Ugbu a, a na-ewere microbiota gut dị ka ihe nwere ike ime iji ghọta usoro ọgwụgwọ nke TCM (Feng et al., 2019). Ọmụmụ ihe ọgbara ọhụrụ na-egosi na eriri afọ microbiota na-arụ ọrụ dị mkpa n'ịkwado homeostasis eriri afọ. Microbiota gut dị mma na-enye aka na nchebe nke eriri afọ nke eriri afọ, metabolism, homeostasis na nzaghachi, na nkwụsị nke pathogen (Thursby na Juge, 2017; Pickard et al., 2017). Ọkpụkpụ eriri afọ microbiota na-emebi physiological na dịghịzi ọrụ nke ahụ mmadụ ozugbo ma ọ bụ na-apụtaghị ìhè, na-ebute mmeghachi omume dị ka afọ ọsịsa (Patel et al., 2016; Zhao na Shen, 2010). Nnyocha egosila na 5-FU gbanwere n'ụzọ dị ịrịba ama nhazi nke microbiota gut na ụmụ oke afọ ọsịsa (Li et al., 2017). Ya mere, mmetụta nke AM na PM na afọ ọsịsa nke 5-FU nwere ike ịgbachitere site na gut microbiota. Agbanyeghị, ma AM na PG naanị yana njikọta nwere ike igbochi afọ ọsịsa nke 5-FU site n'ịgbanwe microbiota gut ka amabeghị.

Iji nyochaa mmetụta mgbochi afọ ọsịsa na usoro dị n'okpuru AM na PG, anyị na-eji 5-FU mee ka ihe atụ nke afọ ọsịsa na ụmụ oke. N'ebe a, anyị lekwasịrị anya na mmetụta ndị nwere ike ịkpata otu na mkpokọta nchịkwa (AP) nkeAtractylodes macrocephalammanụ dị mkpa (AMO) naPanax ginsengngụkọta saponins (PGS), ihe ndị na-arụ ọrụ nke ewepụtara na AM na PG, na afọ ọsịsa, ọrịa eriri afọ na usoro microbial mgbe 5-FU chemotherapy gasịrị.