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Ọnọdụ ojiji na ozi dị mkpa: Ozi a bụ iji gbakwunye, ọ bụghị dochie ndụmọdụ dọkịta gị ma ọ bụ onye na-ahụ maka ahụike na ọ bụghị iji kpuchie ojiji niile, ịkpachara anya, mmekọrịta ma ọ bụ mmetụta ọjọọ. Ozi a nwere ike ọ gaghị adabara ọnọdụ ahụike gị. Egbula oge ma ọ bụ leghara ịchọ ndụmọdụ ahụike ọkachamara n'aka dọkịta gị ma ọ bụ onye nlekọta ahụike ndị ọzọ tozuru oke n'ihi ihe ị gụrụ na WebMD. Ị ga-esoro dọkịta gị ma ọ bụ ọkachamara nlekọta ahụike na-ekwurịta okwu mgbe niile tupu ịmalite, kwụsị, ma ọ bụ gbanwee akụkụ ọ bụla edepụtara nke atụmatụ nlekọta ahụike gị ma ọ bụ ọgwụgwọ yana ikpebi usoro ọgwụgwọ dị mma maka gị.

Enyere ihe nwebiisinka a sitere n'ụdị ndị ahịa ihe nchekwa data Natural Medicines Comprehensive. Ozi sitere na isi iyi a sitere na ihe akaebe na ebumnuche, na enweghị mmetụta azụmahịa. Maka ozi ahụike ọkachamara na ọgwụ eke, lee Ụdị Ọgwụ Ọkachamara Database Comprehensive.

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pisthorchis viverrini (OV) -induced cholangiocarcinoma (CCA) bụ ọrịa kansa a na-ahụkarị n'etiti nwoke na nwanyị, ọkachasị na Thailand. Nnyocha e mere n'oge na-adịbeghị anya gosipụtara na mpụta ethanol nke AL gosipụtara mmetụta mgbochi na ụdị anụmanụ CCA nke OV kpatara na-enweghị nsi doro anya site na nchịkwa ọnụ maka ụbọchị 30 dị ka nsonaazụ sitere na positron emission tomography-computed tomography na nwoke Siria hamsters.7]. Iji chọpụta mmetụta nke AL rhizome na motility nke eriri afọ, a nakweere ụmụ oke atropine-, dopamine-, na 5-hydroxytryptamine (5-HT). Nsonaazụ egosipụtara na 1 mg/kg wepụ nwere ike igbochi dopamine na-akpata mkpofu gastric na motility eriri afọ na-ebelata site na ntụtụ intraperitoneal. Mwepụta na ntinye nke 1000 mg / kg nwere ike igbochi atropine na-ebute obere motility nke eriri afọ, na mwepụta nke 500 mg / kg dose nwere ike igbochi 5-HT na-akpata nsị gastric na obere motility eriri afọ na-ebelata.8]. Na mgbakwunye, AL rụpụtara mmetụta ọnya afọ ọnya na ụdị oke site na mbelata mgbasa ozi mkpali (ie tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), IL-6), na prostaglandin E2 (PGE2). na-abawanye ihe na-eto eto epidermal (EGF) na trefoil factor2 (TFF2) [9]. Ọrịa fungal na-ebute ala na-ebelata 30% mkpụrụ nke ahụekere.10]. N'oge na-adịbeghị anya, a kọrọ na ijikọta ahụekere, AL nwekwara ike igbochi ọrịa fungal na-ebute ala site na mgbochiFusarium oxysporumuto [11]. Mwepụta mmanụ mmanụ (PE) sitere na AL gosipụtara mmetụta mgbochi na BGC-823 na SGC-7901 mkpụrụ ndụ kansa afọ mmadụ. Akụkụ PE nwere ike ibute apoptosis, njide okirikiri cell, yana mgbanwe mgbanwe nke mitochondrial transmembrane [12]. Otu akụkọ na-adịbeghị anya gosipụtara na MeOH wepụ nke AL nwere ike igbochi mmepụta nitric oxide (NO) na lipopolysaccharide-akpali akpali murine macrophage-dị ka RAW264.7 mkpụrụ ndụ ma mee ka granulocyte-colony stimulating factor (G-CSF) secretion na murine nkịtị colonic epithelial sel MCE301. Ọ dịghị bụ free radical [13]. Mwepụta ethanol nke AL gosipụtara mmetụta mgbochi dị mkpa na lipase na IC50 9.06 µg/mL na nyocha nke lipase nke mmadụ, ma gosipụta mmetụta mgbochi oke ibu na ụdị oke oke ibu na-ebute oke abụba na oke oke nke 500 mg. /kg14]. Mkpokọta mmiri sitere na AL gosipụtara ọrụ mmegide megide ndị na-anabata serotonin na mmetụta mgbochi na 5-HT2A / 2C agonist nhọrọ 1- (2,5-dimethoxy-4-iodophenyl) -2-aminopropane na-ebute nzaghachi isi na-atụgharị na ụmụ oke. [15]. Mwepụta mmiri sitere na AL belatara nsi na-akpata triptolide site na nhazi ala nke ngosipụta imeju nke CYP3A. Ka ọ dị ugbu a, AL nwere ike melite mmetụta mgbochi mkpali nke triptolide. Nchọpụta ndị a na-atụ aro na AL nwere ike igbochi nsị na ịbawanye ọrụ ọgwụgwọ nke triptolide site na ngwakọta.